Sherlock Holmes is a 1916 American silent film starring William Gillette as Arthur Conan Doyle's Sherlock Holmes. Directed by Arthur Berthelet, it was produced by Essanay Studios in Chicago. The screenplay was adapted from the 1899 stage play of the same name, which in turn was based on the stories, "A Scandal in Bohemia," "The Final Problem," and A Study in Scarlet by Arthur Conan Doyle.

All surviving prints of the 1916 film Sherlock Holmes were once thought to be lost. However, on October 1, 2014, it was announced that a copy had been discovered in a film archive in France.