Titan A.E. is a 2000 American animated science fiction action-adventure film directed by Don Bluth and Gary Goldman, and starring Matt Damon, Bill Pullman, John Leguizamo, Nathan Lane, Janeane Garofalo and Drew Barrymore. Its title refers to the spacecraft central to the plot with A.E. meaning "After Earth". The animation of the film combines traditional hand-drawn created animation with the extensive use of computer-generated imagery.

The film tells the story of a young man who receives a mission to save humanity and protect the giant ship that can create a new planet, after the hostile alien species have destroyed the planet Earth. Along the way, he joins up with a ship's crew and their captain, who help him race against time and find the ship, before the aliens can destroy it.

Theatrically released on June 16, 2000, by 20th Century Fox in the United States as the third and final project produced by Fox Animation Studios, the film received mixed reviews from critics with praise for its visuals, cast performances and animation but criticism for its characters and story. Financially, the film was unsuccessful at the box office.