Spook Busters is a 1946 American comedy horror film, directed by William Beaudine and starring the comedy team of The Bowery Boys. It is the fourth film in the series of forty eight.

In the film, the Boys are working as pest control agents. They are tasked with removing ghosts from a seemingly abandoned mansion. It is actually inhabited by a mad scientist, who wants to use of the Boys in a brain transplant operation.