Life Itself is a 2018 American psychological drama film written, co-produced and directed by Dan Fogelman. It stars Oscar Isaac, Olivia Wilde, Mandy Patinkin, Olivia Cooke, Laia Costa, Annette Bening, and Antonio Banderas, and follows multiple couples over numerous generations, and their connections to a single event.

The film had its world premiere at the Toronto International Film Festival on September 8, 2018, and was theatrically released in the United States on September 21, 2018, by Amazon Studios. Life Itself was largely panned by critics, who criticized Fogelman's screenplay and direction, and calling it "simultaneously overwrought and underwhelming."