The Misery Index is an American television comedy game show developed for TBS that premiered on October 22, 2019. The show, based on the card game "Shit Happens," is hosted by Jameela Jamil, and stars the four members of The Tenderloins comedy troupe who also star in truTV's Impractical Jokers.Andy Breckman, who created and wrote the TV shows Monk and The Good Cop, created the card game "Shit Happens" for his company Uncle Andy Toys. He developed the TV version with Ben & Dan Newmark of Grandma's House Entertainment.

The show features two competing teams, each composed of a non-celebrity contestant and two members of the Tenderloins, who will "attempt to determine the ranking of hilarious and miserable real-life events--from getting fired to accidentally sexting your grandfather--on a scale of 1–100." Michael Bloom, a senior vice president for TBS, said about the show's premise: "Andy Breckman and the Newmarks have hilariously gamified embarrassment, humiliation, and total misery."Executive producers for the series are Breckman, the Newmark brothers of Grandma's House Entertainment, Howard Klein of 3 Arts Entertainment, Rob Anderson, and showrunner Vin Rubino. The series has run for three seasons so far; the first consisted of ten half-hour episodes, while the second consisted of twenty. In 2020, the series was renewed for a third season which premiered on January 26, 2021.During the July 6, 2022 episode of Talk Is Jericho, podcast titled "The Impractical Jokers Appreciation Society" Vulcano commented that the show was "unceremoniously" not renewed by TBS but that he hoped it could come back at some point.