The Nightly Show with Larry Wilmore is an American late-night panel talk show hosted by Larry Wilmore that aired on Comedy Central from January 19, 2015, to August 18, 2016. The show was a spin-off of The Daily Show, which featured Wilmore as a recurring contributor. It aired Monday through Thursday at 11:30 PM (ET) following The Daily Show. It served as a replacement for The Colbert Report, which aired at the same time-slot from October 2005 to December 2014.

The show has been described as a combination of The Daily Show and Politically Incorrect. It featured Wilmore's scripted take on the news, followed by a panel discussion and later in most episodes a game with his guests. The Nightly Show with Larry Wilmore received a generally positive reception from critics, but ratings fell after Jon Stewart left The Daily Show. The show was canceled on August 15, 2016, due to poor ratings performance.