Squidbillies is an American adult animated sitcom created by Jim Fortier and Dave Willis for Cartoon Network's late night programming block Adult Swim. An unofficial pilot for the series aired on April 1, 2005. The series later made its official debut on October 16, 2005, and ended on December 12, 2021, with a total of 132 episodes over the course of 13 seasons.

The series is about the Cuyler family, an impoverished family of anthropomorphic hillbilly mud squids living in the Georgia region of the Blue Ridge Mountains. The series revolves around the exploits of an alcoholic father (Early), who is often abusive in a comedic way towards his family. His son, Rusty, is desperate for his approval; his mother and grandmother, known in the show as Granny, is often the center of his aggression; and Lily, Early's sister, is mostly unconscious in a pool of her own vomit.

The series also airs in syndication in other countries and has been released on various DVD sets and other forms of home media.