Miss Sherlock (ミス・シャーロック) is a female-led adaptation of Sir Arthur Conan Doyle's Sherlock Holmes detective stories. The show is primarily set in Tokyo, Japan. It is a co-production between HBO Asia and Hulu Japan. Both the main characters, based on Sherlock Holmes and Dr. John Watson, are played by women, Yuko Takeuchi and Shihori Kanjiya respectively and it is the first major series to cast a woman as Holmes.