Bee and PuppyCat is an American animated television series created and written by Natasha Allegri. The series revolves around Bee (voiced by Allyn Rachel), an unemployed woman in her early twenties, who encounters a mysterious creature named PuppyCat (voiced by the Vocaloid program Oliver). She adopts this apparent cat-dog hybrid, and together they go on a series of temporary jobs to pay off her monthly rent. These bizarre jobs take the duo across strange worlds out in space. The original series was produced by Frederator Studios with the animation initially outsourced to South Korean studio Dong Woo Animation for episodes 1 to 6, and to Japanese studio OLM for episodes 7 to 10.

The series originated with a web pilot in 2013, followed by a Kickstarter-supported first season which was released on YouTube from 2014 to 2016.

A second series titled Bee and PuppyCat: Lazy in Space was produced and billed for a 2019 release on VRV, but it was delayed and leaked online in 2020.

Netflix later commissioned three additional episodes re-adapting the pilot and first season, and then packaged these along with the Lazy in Space episodes. The complete rebooted series was released on Netflix in 2022. KaBoom! Studios also published a comic book adaptation from 2014 to 2016.

On January 4, 2023, Genius Brands announced that they would sell a 50% stake in the series to Toho International, the US-based division of Japanese film studio Toho.