The Powerpuff Girls is an American superhero animated television series created by animator Craig McCracken and produced by Hanna-Barbera (later Cartoon Network Studios) for Cartoon Network. The show centers on Blossom, Bubbles, and Buttercup, three kindergarten-aged girls with superpowers. They live in the fictional city of Townsville with their father and creator, a scientist named Professor Utonium, and are frequently called upon by the city's mayor to help fight nearby criminals and other enemies using their powers.

While attending his second year at CalArts in 1992, McCracken created a short film, Whoopass Stew!, about a trio of child superheroes known as the Whoopass Girls, which was only shown at festivals. Following the name change to The Powerpuff Girls, McCracken submitted his student film to Cartoon Network, who aired the series' refined pilot, "Meat Fuzzy Lumpkins", in its animation showcase program World Premiere Toons on February 20, 1995, along with its follow-up, "Crime 101", on January 28, 1996. Network executives gave McCracken the greenlight for a full series, which debuted as a Cartoon Cartoon on November 18, 1998.

The Powerpuff Girls aired on Cartoon Network for six seasons, three specials, and a feature film, with the final episode airing on March 25, 2005. A total of 78 episodes were produced, in addition to the two pilots, a Christmas special, the film, a tenth anniversary special, and a special episode in computer animation. Various spin-off media include an anime, three CD soundtracks, a home video collection, comic books, a series of video games, a 2016 reboot series, and an upcoming reboot series, as well as various licensed merchandise. The series has been nominated for six Emmy Awards, nine Annie Awards, and a Kids' Choice Award during its run.