Powerpuff Girls Z (Japanese: 出ましたっ！パワパフガールズZ, Hepburn: Demashita! Pawapafu Gāruzu Zetto, lit. They're Here! Powerpuff Girls Z) is a 2006 Japanese anime television series created to commemorate the 50th anniversary of Toei Animation. Planned by Cartoon Network and produced by TV Tokyo, Aniplex, and Toei Animation, the series is directed by Iku Ishiguro, with Yoshio Urasawa handling series scripts, Miho Shimogasa (character designer of Cutie Honey Flash and Ultra Maniac and one of the animation directors of Sailor Moon) designing the characters and Hiroshi Nakamura and Taichi Master composing the music. The anime is based on the 1998 American animated television series The Powerpuff Girls, created by Craig McCracken and produced by Cartoon Network.

As production occurred in Japan, The Powerpuff Girls original series creator Craig McCracken was not actively involved with the project. Powerpuff Girls Z aired in Japan on TV Tokyo between July 2006 and June 2007. In addition to Cartoon Network Japan, the anime was also broadcast on AT-X. A manga adaptation by Shiho Komiyuno ran in Shueisha's Ribon magazine between July 2006 and June 2007.

The anime's English-language adaptation was produced in association with Ocean Productions in Canada. It was aired on Cartoon Network in the Philippines and Boomerang in Australia and New Zealand in 2008. Despite owning the IP rights to it, the anime series never aired on Cartoon Network or its sister channel Boomerang in the United States.