The Pruitts of Southampton is an American situation comedy that aired during the 1966-67 season on the ABC network. The show was based on the novel House Party (1954) by Patrick Dennis. It was ABC's attempt to turn female stand-up comic Phyllis Diller into a sitcom comedienne very much in the style of Lucille Ball. Child actress Lisa Loring formerly of TV's The Addams Family also had a small role on the show as Phyllis's daughter

Suzy Pruitt.

The program starred Diller as Phyllis Pruitt, and featured Gypsy Rose Lee and Richard Deacon in supporting roles with Diller feeling the series was an inverted version of The Beverly Hillbillies. The show's producers originally sought comic actress Beatrice Lillie in the Diller role. Exteriors of the Biltmore Estate in Asheville, North Carolina were used as the locale.

In 2002, TV Guide ranked it number 20 on its TV Guide's 50 Worst TV Shows of All Time list.