The Queen and the Conqueror (Spanish: La reina de Indias y el conquistador), is a Colombian historical drama television series created by Johhny Ortiz, and directed by Camilo Villamizar, and Juan Carlos Vásquez. The series revolves around the history that led to the founding of the city of Cartagena de Indias, of major importance in the Americas. The series is recorded in 4K Ultra-high-definition television. The show is filmed in Colombia, specifically in Sierra Nevada de Santa Marta, the banks of the Magdalena River and Palomino, Villa de Leyva, and Santa Fe de Antioquia. It stars Essined Rivera Aponte, and Emmanuel Esparza as the main characters.

The series premiered on streaming on 20 May 2020 on Netflix.