Desire is an American telenovela which debuted at 8:00PM Eastern/7:00PM Central on September 5, 2006, on the American network MyNetworkTV, and ended on December 5. It was produced by Twentieth Television.

The program starred Sofia Milos, Michelle Belegrin, Nate Haden, Kelly Albanese, Zack Silva, Chuti Tiu, Jessie Ward, Tanisha Harper, Will Rolland, Al Bandiero, Kristen Kerr, and Eliana Alexander. Haden and Silva played two brothers on the run from the Gamarras, a New Jersey crime family. They run from Bayonne to Los Angeles and become restaurateurs. Along the way, the pair find themselves on a heated trail of passion, betrayal, and murder over the woman they both loved (played by Belegrin).

The Desire brand is also used as an umbrella name for Twentieth's limited-run serials.

As of 2021, the entire series can be seen on TubiTV.