Cow and Chicken is an American animated comedy television series created by David Feiss for Cartoon Network. It is the third of the network's Cartoon Cartoons. It follows the surreal adventures of two talking animal siblings, Cow and Chicken. They are often antagonized by the Red Guy, a cartoonish version of the Devil who poses as various characters to scam them.

The original pilot appeared as an episode of the animation showcase series What a Cartoon!. The popularity of the original short allowed Hanna-Barbera Cartoons to give it the green light for a full series, which premiered on July 15, 1997. Originally, Cow and Chicken was attached to another segment called I Am Weasel, which was later spun-off into its own half-hour series on June 10, 1999; both shows were the final shows on the network to be produced solely by Hanna-Barbera. It was nominated for two Emmy Awards.