Acting for a Cause is a live read series of classic plays and screenplays created, produced, directed and hosted by Brando Crawford. The script is typically announced days before the event alongside a playbill featuring the cast and an animation on Instagram. The actors have one rehearsal ahead of time. Each reading is organized to raise money for charity. The readings garnered over 500,000 viewers between the first play read on March 27, 2020 and the last announced read on July 31, 2020.

The series has featured young Hollywood actors such as Florence Pugh, Margaret Qualley, Ruby Rose, Madelaine Petsch, Zazie Beetz, David Corenswet, Jacob Elordi, Natalia Dyer, Corbin Bleu, Julia Fox, Tommy Dorfman, Madeline Brewer, Sophia Lillis, Wyatt Oleff, Cameron Monaghan. Recurring participants include Auliʻi Cravalho, Brandon Flynn, Justice Smith, Alex Wolff, Ronen Rubinstein, Jessica Frances Dukes, Mason Alexander Park, Sydney Lemmon, and Xxavier Lavell. While Brando Crawford serves as director and producer for every reading. Alex Wolff co-produced the reading of "This is our Youth", and Xxavier Lavell co-directed the reading of "Hit the Wall".

The reading series was a direct response to the COVID-19 pandemic in the United States.