Mr. & Mrs. Smith is an American spy television series created by Francesca Sloane and Donald Glover, which premiered on February 2, 2024. It is inspired by the 2005 film of the same name, although instead of following a married couple of competing spies like the film, the series stars Glover and Maya Erskine as two strangers paired up as a duo of spies who must live undercover as a married couple; instead of real names, John and Jane Smith are aliases given to the characters and the other agents working for the same organization.

Arnon Milchan, who was a producer on the original film, is an executive producer for the series alongside, among others, Sloane, Glover, Glover's brother Stephen, Hiro Murai, Anthony Katagas, and Michael Schaefer. In May 2024, the series was renewed for a second season.

The show received positive reviews from critics, who particularly praised the performances and Glover and Erskine's chemistry. It received 16 Primetime Emmy Award nominations for its first season, including nominations for Outstanding Drama Series, Outstanding Lead Actor for Glover, Outstanding Lead Actress for Erskine, and five acting nominations for some of the featured guests.