Big Mouth is an American adult animated coming-of-age sitcom created by Andrew Goldberg, Nick Kroll, Mark Levin, and Jennifer Flackett for Netflix. The series aired for eight seasons between 2017 and 2025. The series centers on students based on Kroll and Goldberg's upbringing in suburban New York, with Kroll voicing his fictionalized younger self. Big Mouth explores puberty while embracing an openness about the human body and sex.

The first season, consisting of ten episodes, premiered on Netflix on September 29, 2017, and the second season was released on October 5, 2018. The third season was preceded by a Valentine's Day special episode on February 8, 2019, and the rest of the third season was released on October 4, 2019. In July 2019, Netflix renewed the series through to a sixth season. The fourth season was released on December 4, 2020, and the fifth season was released on November 5, 2021. The sixth season premiered on October 28, 2022. A seventh season premiered on October 20, 2023. In April 2023, the series was renewed for an eighth and final season, making it one of Netflix's longest-running original scripted series ever produced. The final season was released on May 23, 2025.

Since its release, the series has received critical acclaim. A spin-off series titled Human Resources debuted on March 18, 2022, and ran for two seasons, concluding on June 9, 2023.