Santo Richard Loquasto (born July 26, 1944) is an American production designer, scenic designer, and costume designer for stage, film, and dance.His work has included the films Big, Radio Days, Cafe Society, Blue Jasmine, Desperately Seeking Susan, Alice, and Zelig. His work on stage is extensive and includes Hello, Dolly!, Movin' Out, Fosse, Ragtime, The Cherry Orchard, Grand Hotel, Cafe Crown, the ballet Don Quixote, Glengarry Glen Ross, and Fences.

Loquasto has won a British Academy Film Award, five Drama Desk Awards, and has garnered four Tony Awards. He has been nominated for three Academy Awards and a total of twenty-three Tony Awards. In 2004, Loquasto was inducted into the American Theater Hall of Fame.