Murder in Small Town X (sometimes abbreviated MiSTX) is an American reality television series created by George Verschoor, Robert Fisher Jr., and Gordon Cassidy and was hosted by Sgt. Gary Fredo, a California Police Investigator, that aired on Fox from July through September 2001. The series immerses contestants in a fictional town, and challenges them to solve a murder. Each week, one of the contestants is "murdered" (and removed from the show); the final contestant solves the case and wins $250,000.

Although classified as a reality television series, given the format's unique nature, it was more accurately described as a hybrid of a reality TV show, game show, and mystery drama. It is notable for the fact that its winner, New York City fireman Ángel Juarbe Jr., died in the September 11 attacks exactly one week after the show's finale aired.