The Smothers Brothers Show is

an American fantasy sitcom featuring the Smothers Brothers that aired on CBS on Friday nights at 9:30 p.m. ET from September 17, 1965, to April 22, 1966, co-sponsored by Alberto-Culver's VO5 hairdressing products and American Tobacco's Tareyton cigarettes. It was the first television show to feature the Smothers Brothers as regulars, following a series of night club and guest appearances. It lasted one season, consisting of 32 episodes.

It was the network's last sitcom filmed in black-and-white; shortly after its final telecast, all CBS prime-time series were transmitted in color. In 1986, two decades after cancellation, reruns were seen on Nick at Nite.