Night and Day is a British mystery soap opera, produced by Granada Television for LWT, that first broadcast on 6 November 2001 on ITV, and ran until 5 June 2003. The series was launched as part of ITV's new early evening line-up, with an enormous amount of pre-publicity and trailers promoting the series. The series was written and created by screenwriter Caleb Ranson, with other contributors to the series including John Jackson, Jessica Townsend, Cris Cole, Elizabeth Delaney, Jeff Dodds, Robert Fraser, Adrian Hewitt, Martha Jay, Charles Lambert, Ed McCardie, Adrian Pagan, Bradley Quirk, Tony Ramsay and Catherine Stedman. The series opening theme, "Always & Forever", was performed by Kylie Minogue.

At first, the series rated well, even drawing comparisons to series such as Twin Peaks. However, as the series storylines became more bizarre and complex, it began to rate poorly, only gaining a small, cult fanbase, and was pushed to a later timeslot due to the lack of mainstream interest. Subsequently, little more than six months after the series premiered, filming wrapped on 17 May 2002, and the series was later axed by station executives, who cited low ratings as the principal reason. The final episode aired on screen on 5 June 2003.