The New Adventures of Old Christine (often shortened to simply Old Christine) is an American sitcom created by Kari Lizer that aired on CBS from March 13, 2006, to May 12, 2010. The series stars Julia Louis-Dreyfus as Christine Campbell, a single mother balancing her work and personal life while maintaining a close relationship with her ex-husband, Richard, played by Clark Gregg. The show also features Hamish Linklater as Christine’s brother Matthew, Wanda Sykes as her best friend Barb, and Trevor Gagnon as her son Ritchie.

The sitcom revolves around Christine's humorous and often chaotic attempts to keep pace with the changing world around her, especially as she navigates life as a divorcée, while her ex-husband moves on with a younger girlfriend, also named Christine, referred to as "New Christine." Filming primarily took place in Los Angeles, California, with Andy Ackerman directing all 88 episodes.

The New Adventures of Old Christine received positive reviews from critics. Throughout its run, the series received 9 Primetime Emmy Award nominations, with Louis-Dreyfus winning Outstanding Lead Actress in a Comedy Series in 2006.

CBS canceled The New Adventures of Old Christine after five seasons on May 18, 2010.