3×3 Eyes is a Japanese manga series written and illustrated by Yuzo Takada. It was serialized in Kodansha's Seinen manga magazines Young Magazine Kaizokuban and Weekly Young Magazine from 1987 to 2002, spanning to a total of 40 volumes. The English language translation was published by Dark Horse Comics, but was discontinued after eight volumes in 2004.

Two original video animation (OVA) adaptations were released in 1991 and 1995. The first consists of four episodes averaging to half-hour of runtime and the second consists of three averaging out to 45 minutes of runtime. In the United States, the first OVA was first distributed by Streamline Pictures and the second was partially distributed by Orion Home Video shortly after the Japanese releases. Both OVAs were released in their entirety by Manga Entertainment in the United Kingdom. The two OVAs were re-released in the United States by Pioneer Entertainment in 2001. There are also several 3×3 Eyes companion books, drama CDs, and video games, only released in Japan.

In 1993, 3×3 Eyes won the Kodansha Manga Award for the shōnen category.