Brothers & Sisters is an American family drama television series that centers on the Walker family and their lives in Los Angeles and Pasadena, California. The series aired for five seasons on ABC from September 24, 2006, to May 8, 2011. For the entirety of its run, it was broadcast on Sunday nights following Desperate Housewives.

Brothers & Sisters features an ensemble cast led by Sally Field as Nora Walker, with Rachel Griffiths as Sarah, Calista Flockhart as Kitty, Balthazar Getty as Tommy, Matthew Rhys as Kevin and Dave Annable as Justin Walker, Nora's grown children. Patricia Wettig co-starred as Holly Harper, with Emily VanCamp later joining the cast as Rebecca Harper, as well as Ron Rifkin as Saul Holden.

Throughout the series, Field won both a Primetime Emmy Award and a Screen Actors Guild Award for playing Nora, while Griffiths received nominations for two Primetime Emmy Awards and two Golden Globe Awards for portraying Sarah Walker.

On May 6, 2011, ABC canceled the series after five seasons.