Route 66 is an American adventure crime drama television series that premiered on CBS on October 7, 1960, and ran until March 20, 1964, for a total of 116 episodes. The series was created by Herbert B. Leonard and Stirling Silliphant, who were also responsible for the ABC drama Naked City, from which Route 66 was an indirect spin-off. Both series employed a format with elements of both traditional drama and anthology drama, but the difference was where the shows were set: Naked City was set in New York City, while Route 66 had its setting change from week to week, with each episode being shot on location.

Route 66 followed two young men traversing the United States in a Chevrolet Corvette convertible, and the events and consequences surrounding their journeys. Martin Milner starred as Tod Stiles, a recent college graduate with no future prospects because of circumstances beyond his control. He was originally joined on his travels by Buz Murdock (played by George Maharis), a friend and former employee of his father's, with the character leaving midway through the third season after contracting echovirus. Near the end of the third season, Tod met a recently discharged Vietnam veteran named Lincoln Case, played by Glenn Corbett, who decided to follow Tod on his travels and stayed with him until the final episode.