MythBusters is a science entertainment television series developed by Peter Rees and produced by Australia's Beyond Television Productions. The series premiered on the Discovery Channel on January 23, 2003. It was broadcast internationally by many television networks and other Discovery channels worldwide. The show's original hosts, special effects experts Adam Savage and Jamie Hyneman, used elements of the scientific method to test the validity of rumors, myths, movie scenes, adages, Internet videos, and news stories.

Filmed in San Francisco and edited in Artarmon, New South Wales, MythBusters aired 282 total episodes before its cancellation at the end of the 2016 season in March. Planning and some experimentation took place at Hyneman's workshops in San Francisco; experiments requiring more space or special accommodations were filmed on location, typically around the San Francisco Bay Area and other locations in northern California, going to other states or even countries on occasion when required. During the second season, members of Savage's and Hyneman's behind-the-scenes team were organized into a second team of MythBusters ("The Build Team"). They generally tested myths separately from the main duo and operated from another workshop. This arrangement continued until August 2014, when it was announced at the end of "Plane Boarding" that Tory Belleci, Kari Byron, and Grant Imahara would be leaving the show. Savage and Hyneman subsequently hosted the final two seasons alone. On October 21, 2015, it was announced that MythBusters would air its 14th and final season in 2016. The show aired its final episode with the original cast on March 6, 2016.

Kari Byron, Tory Belleci, and Grant Imahara, former MythBusters stars, led the Netflix show White Rabbit Project, which premiered on December 9, 2016. Through experiments and tests, they delve into topics like jailbreaks, superpower technology, heists, and WWII weapons. The series was canceled after one season.

On November 15, 2017, sister network Science Channel revived the series with new hosts Jon Lung and Brian Louden, who were selected via the competition spin-off MythBusters: The Search. The revival was filmed in Santa Clarita and on location in other parts of Southern California, airing for two seasons that lasted until 2018. Savage would later return in MythBusters Jr., a spin-off featuring children.

In 2021, Beyond Television produced and aired a new title of the franchise, Motor Mythbusters, for MotorTrend. Belleci returned for the series and was joined by engineer Bisi Ezerioha and mechanic Faye Hadley. The series focused on testing myths and urban legends about automobiles.

Also in 2021, excerpts of the original seasons (2003-2016) were used to produce "Mythbusters: There's Your Problem!" for several streaming services. In this repackaging, each episode is summarized to include only the episodes experiments and conclusions.

The term MythBusters may be used to refer to both the program and the cast members who test the experiments.