Little Britain USA is an American spin-off-continuation of British sketch show, Little Britain, produced by and aired on HBO.

As in the British series, Matt Lucas and David Walliams play most of the characters: originals such as Lou and Andy, Daffyd Thomas, Sebastian Love, Emily Howard, Marjorie Dawes and Vicky Pollard, as well as new characters not previously seen in the British series. The series is narrated by Tom Baker, the narrator from the entirety of the original British series.

The first series started filming in March 2008 in Wilmington, North Carolina.

HBO showed the first episode of the season in the United States on September 28, 2008; The Movie Network broadcast it in Canada the same day, followed by BBC One on October 3 in the UK.

New guest-stars include Rosie O'Donnell, Rachael Harris, Bob Stephenson, Paul Rudd (as the President of France), Hilarie Burton, Vivica A. Fox, and Sting. Michael Patrick Jann served as executive producer of the series and directed most of the shows. David Schwimmer directed studio-based segments of the show.

Rosie O'Donnell also makes an appearance in a "Fat Fighters" segment.

The series was released on DVD in the United Kingdom by 2entertain on 24 November 2008.