Ice Age: Collision Course is a 2016 American animated adventure comedy film produced by Blue Sky Studios and distributed by 20th Century Fox. It is the sequel to Ice Age: Continental Drift (2012) and the fifth installment in the Ice Age film series. The film was directed by Michael Thurmeier and co-directed by Galen T. Chu, from a screenplay written by Michael Wilson, Michael Berg, and Yoni Brenner, based on a story conceived by Aubrey Solomon. Ray Romano, John Leguizamo, Denis Leary, Keke Palmer, Josh Peck, Simon Pegg, Seann William Scott, Jennifer Lopez and Queen Latifah reprise their roles from previous films, with Adam DeVine, Jesse Tyler Ferguson, Max Greenfield, Jessie J and Nick Offerman voicing new characters. In the film, Scrat is propelled into outer space in an abandoned spaceship during an attempt to bury his acorn and accidentally sends a giant asteroid towards Earth. Manny, the Herd and Buck must go on a life-or-death mission to find a way to fend it off.

The film premiered at the Sydney Film Festival on June 19, 2016, and was released in the United States on July 22. The film received generally negative reviews from critics, who felt like the franchise had run its course, and felt that the film was the killing blow for the franchise. It grossed $408.5 million worldwide against a $105 million production budget, grossing below expectations in the US market, but faring better internationally. Ice Age: Collision Course was the fifth and final film in the Ice Age series to be produced by Blue Sky Studios before the studio's closure on April 10, 2021. A standalone spin-off, titled The Ice Age Adventures of Buck Wild, was released in January 2022 on Disney+, with Simon Pegg (voice of Buck) being the only cast member to reprise his role. A sequel, Ice Age 6, is scheduled for release on December 18, 2026.