The Ant Bully is a 2006 American animated fantasy adventure comedy film written and directed by John A. Davis and based on the 1999 children's book of the same name by John Nickle. Starring the voices of Julia Roberts, Nicolas Cage, Meryl Streep, Paul Giamatti, Regina King, Bruce Campbell and Lily Tomlin, it was produced by Tom Hanks and Gary Goetzman's Playtone, Davis and Keith Alcorn's DNA Productions, and Legendary Pictures in their first animated film, and distributed by Warner Bros. Pictures.

Set in suburban Las Vegas, The Ant Bully follows Lucas Nickle (Zach Tyler Eisen), a 10-year-old destructive boy who is neglected by his family (Cheri Oteri and Larry Miller) and bullied by Steve (Myles Jeffrey) and his friends (Jake T. Austin). He attacks the nearby ant colony out of frustration, but Zoc (Cage), a wizard ant, creates a potion to shrink Lucas. After being shrunk by Zoc, Lucas must join forces with his new friends (Roberts, King, and Campbell) to defeat Stan Beals (Giamatti), an exterminator who threatens their colony upon signing the contract.

Released on July 28, 2006, The Ant Bully received mixed reviews from critics and became a box-office failure, grossing $55 million against its $50 million budget. Due to this, many DNA employees were laid off, leading to the studio's closure. This was Ricardo Montalbán's final film role before his death in 2009.