Sethurama Iyer CBI is a 2004 Indian Malayalam-language mystery crime film directed by K. Madhu and written by S. N. Swamy. It stars Mammootty in the title role, alongside Mukesh and Jagathy Sreekumar in supporting roles. Shyam composed the background score for the film.

The film is the third installment in the CBI film series, featuring Mammootty as CBI officer Sethurama Iyer. The film was a blockbuster and was the highest-grossing film of the year collecting around distributors share of ₹4 crore and a gross around ₹10 crore. The success of the film made Mammootty "Man of the year". The base story and initial scenes are adopted from Arthur Hailey's novel Detective. Some of the scenes of the film are also loosely based on the 2001 Aluva massacre.