Sethurama Iyer CBI is a 2004 Malayalam-language mystery crime film directed by K Madhu.The movie is written by S. N. Swami, and The movie stars Mammootty in title role. Actors Mukesh and Jagathy Sreekumar played important supporting roles. Shyam composed the background score for the film.

This film is the third in the series of the CBI investigative thrillers featuring Mammootty as CBI officer Sethurama Iyer.This film was a Blockbuster and was the highest-grossing film of the year collecting around distributors share of ₹4 crore and a gross around ₹10 crore The success of this movie made Mammootty "Man of the year" The base story and initial scenes are adopted from Arthur Hailey's Novel Detective. Some of the scenes of the movie are also loosely based on the 2001 Aluva massacre.