Custer's Last Stand is a 1936 American film serial based on the historical Custer's Last Stand at the Little Bighorn River. It was directed by Elmer Clifton, and starred Rex Lease, William Farnum and Jack Mulhall. It was produced by the Poverty Row studio Stage & Screen Productions, which went bust shortly afterwards as a victim of the Great Depression. This serial stars many famous and popular B-Western actors as well as silent serial star Helen Gibson playing Calamity Jane, Frank McGlynn Jr. as General Custer, and Allen Greer as Wild Bill Hickok.

In April of the same year, the serial was edited into an 84-minute feature film, which was released under the same name.