The Lone Rider in Ghost Town is a 1941 American western film directed by Sam Newfield and written by Joseph O'Donnell. The film stars George Houston as the Lone Rider and Al St. John as his sidekick "Fuzzy" Jones, with Rebel Randall, Budd Buster, Frank Hagney and Stephen Chase. The film was released on May 16, 1941, by Producers Releasing Corporation.

This is the third movie in the Lone Rider series, which spans seventeen films—eleven starring George Houston, and a further six starring Robert Livingston.

Houston, once an opera singer, sang four songs in this film: "Old Cactus Joe", "In Old Spring Valley", "Sweet Suzanna" and "Under Prairie Skies". The songs were written by Johnny Lange and Lew Porter. This film was later released on DVD as Ghost Mine.