Scooby-Doo and the Cyber Chase is a 2001 American direct-to-video animated science fiction comedy mystery film, and the fourth in a series of direct-to-video animated films based on the Scooby-Doo franchise. It was released on October 9, 2001. The film was produced by Hanna-Barbera Cartoons and Warner Bros. Animation. In spite of its grimmer atmosphere, it also has a lighter tone, similar to its predecessor, Scooby-Doo and the Alien Invaders.

It is the final Hanna-Barbera production to be executive produced by both William Hanna and Joseph Barbera before Hanna's death on March 22, 2001 and was dedicated in his memory. It is also the fourth and final Scooby-Doo direct-to-video film to be animated overseas by Japanese animation studio Mook Animation and the first film to use digital ink and paint. This film, along with Aloha, Scooby-Doo!, was part of the first Scooby-Doo! animated films to be re-released on Blu-ray on April 5, 2011.

This was also the first film to feature Grey DeLisle as the voice of Daphne Blake after the death of Mary Kay Bergman in 1999. It was also the last film where Scott Innes voiced Scooby-Doo and Shaggy, as well as the last film where B. J. Ward voiced Velma. This was the last production released by Hanna-Barbera, after the studio was absorbed into Warner Bros. Animation seven months before its release.