Scooby-Doo! and the Monster of Mexico is a 2003 American direct-to-video animated adventure film; the sixth in a series of direct-to-video films based upon the Scooby-Doo Saturday morning cartoons. It was released on September 30, 2003, and it was produced by Warner Bros. Animation.

It is the second and final film (after Scooby-Doo! and the Legend of the Vampire) to briefly reunite the surviving or available voice cast from the original 1969 series, with Frank Welker voicing Scooby-Doo in place of the late Don Messick. The film also marks the last time Nicole Jaffe and Heather North voice Velma and Daphne, respectively, before North's death on November 29, 2017.