Of Mice and Men is a 1992 American period drama film based on John Steinbeck's 1937 novella of the same name and is the fourth film adaptation of the novella. The first was the 1939 film of the same name, the second was in 1968, the third was in 1981, and the fourth was in 1992. Directed and produced by Gary Sinise, the film features Sinise as George Milton, alongside John Malkovich as Lennie Small, with Casey Siemaszko as Curley, John Terry as Slim, Ray Walston as Candy, Joe Morton as Crooks, and Sherilyn Fenn as Curley's wife.

Horton Foote adapted the story for film. Its plot centers on George and the intellectually disabled Lennie, two farm workers who travel together and dream of one day owning their own land. The film explores themes of discrimination, loneliness, and the American Dream, as well as the desire for a place to call home.

Of Mice and Men took part in the 1992 Cannes Film Festival, where Sinise was nominated for the Palme d'Or award, given to the director of the best-featured film. After the film debuted in the United States on October 2, 1992, it received acclaim from critics.