Marmaduke is a 2010 American comedy film based on Brad Anderson's comic strip of the same name. The film was directed by Tom Dey and stars an ensemble cast consisting of Owen Wilson (as the title character), Lee Pace, Judy Greer, William H. Macy, Steve Coogan, Sam Elliott, Fergie, George Lopez, Christopher Mintz-Plasse, Emma Stone, Kiefer Sutherland, and Marlon Wayans. It centers on a Great Dane named Marmaduke (voiced by Wilson) who moves with his family from Kansas to Orange County and faces challengers to fit in with other dogs. The film was released in the United States on June 4, 2010 by 20th Century Fox. It received generally negative reviews from critics and grossed $90 million worldwide against a production budget of $50 million. An animated sequel, was released on May 6, 2022.