The 2006 No Mercy was the ninth No Mercy professional wrestling pay-per-view (PPV) event produced by World Wrestling Entertainment (WWE). It was held exclusively for WWE Talent from the promotion's SmackDown! brand division. The event took place on October 8, 2006, from the RBC Center in Raleigh, North Carolina. It was the final brand-exclusive No Mercy during the first brand extension, as brand-exclusive PPVs were discontinued following WrestleMania 23 in April 2007. It was also the last No Mercy to be SmackDown-exclusive until the 2016 event during the second brand extension when brand-exclusive PPVs returned.

The main event was a fatal four-way match for the World Heavyweight Championship between defending champion King Booker, Bobby Lashley, Batista, and Finlay, which Booker won after pinning Finlay. One of the predominant matches on the card was Mr. Kennedy versus The Undertaker, which Kennedy won after Undertaker was disqualified. Another primary match on the undercard was Rey Mysterio versus Chavo Guerrero in a Falls Count Anywhere match. Mysterio won the match by pinning Guerrero after a completing crossbody off a rail. Montel Vontavious Porter (MVP) also made his WWE in-ring debut at the event by beating Marty Garner.