The 2008 No Way Out was the 10th No Way Out professional wrestling pay-per-view (PPV) event produced by World Wrestling Entertainment (WWE). It was held for wrestlers from the promotion's Raw, SmackDown, and ECW brand divisions. The event took place on February 17, 2008, at the Thomas & Mack Center in the Las Vegas suburb of Paradise, Nevada.

The main match on the Raw brand was an Elimination Chamber match to determine the number one contender for the WWE Championship at WrestleMania XXIV. Triple H won the match after last eliminating Jeff Hardy. The predominant match on the SmackDown brand was Edge versus Rey Mysterio for the World Heavyweight Championship, in which Edge won after spearing Mysterio in mid-air. The primary match on the ECW brand was Chavo Guerrero Jr. versus CM Punk for the ECW Championship. Guerrero won the match and retained the title after pinning Punk following a frog splash. The predominant match on the Raw brand was Randy Orton versus John Cena for the WWE Championship, which Cena won after Orton disqualified himself. The featured match on the undercard was an Elimination Chamber match to determine the number one contender to the World Heavyweight Championship at WrestleMania XXIV, which was won by The Undertaker. No Way Out marked the WWE return of The Big Show who left the company in February 2007 and an appearance by professional boxer Floyd Mayweather, Jr.

Presented by THQ's Frontlines: Fuel of War, the event had 329,000 buys, up on the No Way Out 2007 figure of 218,000 buys.