Cartoon All-Stars to the Rescue is a 1990 American animated children comedy-drama social guidance film starring many characters from several animated television series at the time of its release. The plot follows Michael, a teenager who is using marijuana, leaving his family worried. When his younger sister Corey's piggy bank goes missing one morning, cartoon characters come to life from various items in her room and find it in Michael's room along with his stash of drugs, so they give him an intervention in the form of a fantasy journey to teach him the adverse consequences of drug use.

McDonald's released a VHS home video edition of the special distributed by Buena Vista Home Video, which opened with an introduction from President George H. W. Bush, First Lady Barbara Bush and their dog, Millie. It was produced by the Academy of Television Arts & Sciences Foundation and Southern Star Productions, and was animated overseas by Wang Film Productions. The musical number "Wonderful Ways to Say No" was written by Academy Award-winning composer, Alan Menken and lyricist Howard Ashman, who also wrote the songs for Walt Disney Animation Studios' The Little Mermaid, Beauty and the Beast, and Aladdin.

Financed by McDonald's, Ronald McDonald Children's Charities, it was originally simulcast for a limited time on April 21, 1990, on all four major American television networks (by supporting their Saturday morning characters): ABC, CBS, NBC, and Fox, and most independent stations, as well as various cable networks.

The special was the first production since the Looney Tunes short The Iceman Ducketh to feature Bugs Bunny and Daffy Duck together.