The 2021 Elimination Chamber (known as No Escape in Germany) was a professional wrestling event produced by WWE. It was the 11th Elimination Chamber event and took place on February 21, 2021, from the WWE ThunderDome, hosted at Tropicana Field in St. Petersburg, Florida. The event aired via pay-per-view (PPV) and livestreaming and featured wrestlers from the promotion's Raw and SmackDown brand divisions. It was WWE's final pay-per-view to be available to livestream on the standalone version of the American WWE Network before the launch of Peacock's WWE Network channel in the United States on March 18; the standalone version of the American WWE Network itself shut down on April 4. This also marked the last Elimination Chamber to be held in the United States.

Seven matches were contested at the event, including one on the Kickoff pre-show. In an impromptu main event, The Miz cashed in his Money in the Bank contract and defeated Drew McIntyre to win the WWE Championship after McIntyre had retained the title in Raw's Elimination Chamber match. In the opening bout, Daniel Bryan won SmackDown's Elimination Chamber match to earn an immediate Universal Championship match against Roman Reigns, who retained the title against Bryan. In another prominent match, Riddle defeated John Morrison and defending champion Bobby Lashley to win the United States Championship. This was the first Elimination Chamber to not feature a women's Elimination Chamber match since its debut in 2018.