Guru Sishyan (pronounced [ɡuɾu siʂjan] transl. Master and Disciple) is a 1988 Indian Tamil-language action comedy film directed by S. P. Muthuraman. A remake of the Hindi film Insaf Ki Pukar (1987), it stars Rajinikanth, Prabhu, Seetha and Gautami with Pandiyan, Cho Ramaswamy, Ravichandran, Radha Ravi, Senthamarai, Vinu Chakravarthy and Manorama in supporting roles. The film is about two ex-convicts who set out to prove the innocence of their wrongfully imprisoned fellow convict.

Meena Panchu Arunachalam produced Guru Sishyan under the production company P. A. Art Productions. The screenplay was written by her husband Panchu Arunachalam. The cinematography was handled by T. S. Vinayagam, the editing was by R. Vittal and C. Lancy, and the art direction was by B. Chalam. The film is Gautami's debut role in Tamil cinema, and the first film in which Rajinikanth and Prabhu co-starred. Filming took place primarily in Mysore and Chennai, and was completed in 25 days.

Guru Sishyan was released on 13 April 1988 during the Puthandu (Tamil New Year) holiday. Despite being released at a time of political turmoil in Tamil Nadu after the death of chief minister M. G. Ramachandran months earlier, Guru Sishyan, which includes many political references, became a commercial success, running in theatres for over 175 days.