Mr. & Mrs. Smith is a 2005 American action comedy film directed by Doug Liman and written by Simon Kinberg. The film stars Brad Pitt and Angelina Jolie as a bored upper middle class married couple, who are surprised to learn that they are assassins belonging to competing agencies and that they have been assigned to kill each other. Incidentally, the filming marked the beginning of Pitt and Jolie's real-life personal relationship, which would later result in a romantic relationship, marriage, and children from 2005 to 2016.

Mr. & Mrs. Smith was released in the United States on June 10, 2005 and received mixed reviews from critics, who praised Pitt and Jolie's performances and chemistry but criticized the screenplay. The film was a box-office success, grossing $487.3 million worldwide and becoming the seventh highest-grossing film of 2005. In 2024, a television series of the same name loosely inspired by the film premiered on Amazon Prime Video, starring Donald Glover and Maya Erskine as two strangers paired up as spies and posing as a married couple; producer Arnon Milchan is the only cast or crew member returning from the original film.