Hyde and Go Tweet is a 1960 Warner Bros. Merrie Melodies animated short directed by Friz Freleng. All of the voices were performed by Mel Blanc. The short was released on May 14, 1960, and stars Tweety and Sylvester.

The short is the third directed by Freleng based on Robert Louis Stevenson's 1886 novella Strange Case of Dr. Jekyll and Mr. Hyde. The title is a play on the game hide and go seek. It was featured in the film Daffy Duck's Quackbusters, with new animation showing Sylvester in Daffy's office.