Jesse James is a 1939 American Western film directed by Henry King and starring Tyrone Power, Henry Fonda, Nancy Kelly and Randolph Scott. Written by Nunnally Johnson, the film is loosely based on the life of Jesse James, the outlaw from whom the film derives its name. The supporting cast includes Henry Hull, John Carradine, Brian Donlevy, Jane Darwell and Lon Chaney, Jr.

The American Humane Association began to oversee filmmaking after a horse appeared to die when it was driven off a cliff on set. The film has been described by the British Channel 4 website as being "notorious for its historical inaccuracy."