Fail Safe is a 1964 Cold War thriller film directed by Sidney Lumet, based on the 1962 novel of the same name by Eugene Burdick and Harvey Wheeler. The film follows a crisis caused by a critical error that sends a group of U.S. bombers to destroy Moscow, and the ensuing attempts to stop the bomber group before it can deploy a nuclear first strike. The film features performances by actors Henry Fonda, Dan O'Herlihy, Walter Matthau, Frank Overton, Fritz Weaver, Edward Binns, Larry Hagman, Sorrell Booke, Dana Elcar and Dom DeLuise.

In 2000, the novel was adapted again as a televised play starring George Clooney, Richard Dreyfuss and Noah Wyle, and broadcast live in black and white on CBS.