Daffy Duck's Quackbusters is a 1988 animated compilation film featuring classic Warner Bros. Cartoons shorts and animated bridging sequences, starring Daffy Duck. The film was released to theaters by Warner Bros. on September 24, 1988. It was the final theatrical production in which Mel Blanc provided the voices of the various Looney Tunes characters before his death on July 10, 1989.

Unlike previous compilation films, Quackbusters uses pre-existing music from older Looney Tunes shorts composed by Carl Stalling, Milt Franklyn and William Lava for both the new animation and classic footage. It was also one of the two compilation films of classic Warner Bros. cartoon shorts not composed by Robert J. Walsh (the other being 1979's The Bugs Bunny/Road Runner Movie, which was composed by Dean Elliott).

Similar to The Looney Looney Looney Bugs Bunny Movie, which was preceded with the Oscar-winning Knighty Knight Bugs (1958), Quackbusters is preceded with the exclusive short The Night of the Living Duck (1988). This film is inspired by Ghostbusters. Most of the films included in the compilation have a comedy horror theme, with stories involving spirit possession, exorcism, Transylvanian vampires, magic words, and Yetis. This was the only Looney Tunes compilation film to be aired on HBO in the early 1990s. It later aired on Cartoon Network.