Milo Murphy's Law is an American animated comedy television series created by Dan Povenmire and Jeff "Swampy" Marsh for Disney Channel and Disney XD. The series premiered on October 3, 2016, on Disney XD. It revolves around the title character, Milo Murphy, who is a descendant of Edward A. Murphy Jr., the namesake of Murphy's law, which states that anything that can go wrong will go wrong. The series takes place in the same universe as Povenmire and Marsh's previous series Phineas and Ferb, with multiple references to the show occurring across season one, culminating in a crossover at the beginning of the second season and continuing throughout with other plot threads from the former series.

Although working on a new show, Povenmire announced that he and Marsh "…would both really love to do more Milo Murphy…I'm willing to do more than one show at a time," and according to Povenmire, a possible third season hinged on its Disney+ viewership.