Yu-Gi-Oh! 5D's (遊☆戯☆王5D's, Yūgiō Faibu Dīzu) is the second main spin-off of the Yu-Gi-Oh! franchise, succeeding Yu-Gi-Oh! GX, in celebration of the 40th anniversary of Weekly Shōnen Jump and the 15th anniversary of V Jump. The series aired from April 2008 to March 2011.

The story focuses on characters playing a card game called Duel Monsters. This series introduces Synchro Monsters to the Yu-Gi-Oh! Trading Card Game. A new method of duelling exists where motorcycle-like vehicles called D-Wheels (Duel Runners in the English version) are used, and the duelists engage in games called Riding Duels (Turbo Duels in the English version). The show is set in the distant future, where the upper-class population live in Neo Domino City (New Domino City in the English version) and the lower class in a remote island where Domino's sewage is transported, Satellite. Yusei Fudo, the 18-year-old protagonist, lives in Satellite and makes it his objective to reach his rival Jack Atlas, who lives in Neo Domino. The series focuses on the five Signers, people embodied with a mark of one of the legendary Five Dragons who serve an ancient deity called the Crimson Dragon, their conflict with the Dark Signers, and the Three Emperors of Iliaster.

As with the previous two anime series (Yu-Gi-Oh! Duel Monsters and Yu-Gi-Oh! GX), Yu-Gi-Oh! 5D's was acquired by 4Kids Entertainment for broadcasting in the United States in September 2008. The series aired on The CW4Kids, from September 13, 2008 to September 10, 2011, though 31 episodes were left unaired as well as undubbed. The English-language version premiered on July 24 at San Diego Comic-Con 2008, where the first English-dubbed episode was previewed. Like the previous two English dubs, changes have been made to the plot, cards, and character names. On June 1, 2009, the series began airing 5 days a week on Cartoon Network. A manga based on the show began serialization in V Jump monthly Magazine from August 2009 to January 2015.

The series was succeeded by Yu-Gi-Oh! Zexal.