Yu-Gi-Oh! Zexal (遊☆戯☆王ZEXAL, Yūgiō Zearu, pronounced "Zeyal"), stylized as Yu-Gi-Oh! ZEXAL, is a Japanese manga and anime series and the third spin-off of the Yu-Gi-Oh! franchise, after the preceding Yu-Gi-Oh! 5D's. The manga began serialization in Shueisha's V Jump magazine from December 2010 to June 2015 and is licensed in North America by Viz Media. The anime series was produced by Nihon Ad Systems and TV Tokyo, and its animation was done by Gallop. It aired on TV Tokyo from April 2011 to September 2012, with an English-language version airing in North America between October 2011 and August 2013. A sequel series, titled Yu-Gi-Oh! Zexal II (遊☆戯☆王ZEXAL II, Yūgiō Zearu Sekando, pronounced "Ze-al Second"), aired in Japan from October 2012 to March 2014 and in North America from June 2013 to January 2016.

The series aired on The CW as part of the Toonzai and, later, Vortexx Saturday morning blocks. The series was later broadcast on Nicktoons starting April 12, 2013. After Vortexx ended, new episodes were streamed to Hulu beginning July 14, 2014. In Canada, the series aired on YTV starting June 2, 2012, while new episodes of Zexal II moved to Teletoon on May 4, 2014.

The series was succeeded by Yu-Gi-Oh! Arc-V.